Evidence Reviews
Summaries of systematic reviews and meta-analyses relevant to natural medicine. Includes only content rated Strong or Moderate evidence.
19 items with Strong or Moderate evidence rating
Aging & Longevity
Longevity science has advanced dramatically, identifying cellular mechanisms of aging including telomere shortening, epigenetic ch...
Ashwagandha
Ashwagandha is an adaptogenic herb with the strongest clinical evidence for reducing perceived stress, lowering cortisol, and impr...
Autoimmune Disorders
Autoimmune disorders involve immune system dysregulation where the body attacks its own tissues. Over 80 recognized conditions aff...
Berberine
Berberine is an alkaloid compound found in barberry, goldenseal, and Oregon grape with some of the strongest human clinical eviden...
Boswellia
Boswellia serrata (Indian frankincense) is a resin with clinically demonstrated anti-inflammatory effects, particularly for joint ...
Chronic Inflammation
Chronic low-grade inflammation underlies most major diseases including cardiovascular disease, type 2 diabetes, cancer, and neurod...
CoQ10 (Coenzyme Q10)
CoQ10 is an endogenous antioxidant and critical component of mitochondrial energy production. Evidence supports supplementation fo...
Curcumin
Curcumin is the primary bioactive compound in turmeric with extensive research on anti-inflammatory and antioxidant effects. Multi...
Echinacea
Echinacea is one of the most widely used herbs for immune support, with a large clinical evidence base. Meta-analyses suggest mode...
Gut Health
Gut health encompasses intestinal barrier integrity, gut microbiome diversity, digestive function, and gut-brain axis communicatio...
Immune Modulation
Immune modulation refers to the regulation of immune responses - either stimulating immune activity (in infection vulnerability or...
Irritable Bowel Syndrome (IBS)
IBS is a functional gastrointestinal disorder affecting 10-15% of the population. Multiple natural approaches have clinical eviden...
Magnesium
Magnesium is an essential mineral cofactor in over 300 enzymatic reactions. Suboptimal intake is extremely common in Western popul...
Mitochondrial Health
Mitochondria are the primary energy-producing organelles of every cell. Mitochondrial dysfunction is increasingly recognized as a ...
NAC (N-Acetylcysteine)
NAC (N-acetylcysteine) is a precursor to glutathione, the body's primary endogenous antioxidant. FDA-approved as a pharmaceutical ...
Omega-3 Fatty Acids
Omega-3 fatty acids (EPA and DHA) have some of the strongest evidence among supplements for cardiovascular risk reduction, triglyc...
Probiotics
Probiotics are live microorganisms with a large and growing evidence base. Strongest evidence supports use for antibiotic-associat...
Sleep Health
Sleep is one of the most evidence-supported pillars of health. Poor sleep is associated with increased risk of cardiovascular dise...
Vitamin D
Vitamin D is a fat-soluble vitamin synthesized in the skin upon UV exposure and found in limited dietary sources. Deficiency is ex...